NO170760C - Analogifremgangsmaate for fremstilling av terapeutisk aktive nafthalenderivater - Google Patents

Analogifremgangsmaate for fremstilling av terapeutisk aktive nafthalenderivater

Info

Publication number
NO170760C
NO170760C NO855355A NO855355A NO170760C NO 170760 C NO170760 C NO 170760C NO 855355 A NO855355 A NO 855355A NO 855355 A NO855355 A NO 855355A NO 170760 C NO170760 C NO 170760C
Authority
NO
Norway
Prior art keywords
sup
formula
derivatives
naphense
preparation
Prior art date
Application number
NO855355A
Other languages
English (en)
Norwegian (no)
Other versions
NO170760B (no
NO855355L (no
Inventor
Tameo Iwasaki
Kohki Takashima
Original Assignee
Tanabe Seiyaku Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tanabe Seiyaku Co filed Critical Tanabe Seiyaku Co
Publication of NO855355L publication Critical patent/NO855355L/no
Publication of NO170760B publication Critical patent/NO170760B/no
Publication of NO170760C publication Critical patent/NO170760C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • C07C69/94—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of polycyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/92—Naphthofurans; Hydrogenated naphthofurans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C63/00—Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings
    • C07C63/33—Polycyclic acids
    • C07C63/337—Polycyclic acids with carboxyl groups bound to condensed ring systems
    • C07C63/34—Polycyclic acids with carboxyl groups bound to condensed ring systems containing two condensed rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
    • C07C65/24—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/70—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with ring systems containing two or more relevant rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Furan Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicinal Preparation (AREA)
  • Lubricants (AREA)
  • Fats And Perfumes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Saccharide Compounds (AREA)
NO855355A 1985-01-10 1985-12-30 Analogifremgangsmaate for fremstilling av terapeutisk aktive nafthalenderivater NO170760C (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP309085 1985-01-10

Publications (3)

Publication Number Publication Date
NO855355L NO855355L (no) 1986-07-11
NO170760B NO170760B (no) 1992-08-24
NO170760C true NO170760C (no) 1992-12-02

Family

ID=11547645

Family Applications (1)

Application Number Title Priority Date Filing Date
NO855355A NO170760C (no) 1985-01-10 1985-12-30 Analogifremgangsmaate for fremstilling av terapeutisk aktive nafthalenderivater

Country Status (18)

Country Link
US (2) US4771072A (en])
EP (1) EP0188248B1 (en])
JP (3) JPS61267541A (en])
KR (1) KR890001884B1 (en])
CN (1) CN1006464B (en])
AT (1) ATE54441T1 (en])
AU (1) AU584153B2 (en])
BG (2) BG45383A3 (en])
DD (1) DD270529A5 (en])
DE (1) DE3672501D1 (en])
ES (2) ES8705837A1 (en])
FI (1) FI87557C (en])
HU (1) HU196737B (en])
IL (1) IL91117A0 (en])
MY (1) MY101268A (en])
NO (1) NO170760C (en])
PH (1) PH22105A (en])
PT (1) PT81814B (en])

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4644072A (en) * 1985-04-12 1987-02-17 Bristol-Myers Company Intermediates for the production of epipodophyllotoxin and related compounds and processes for the preparation and use thereof
US5011948A (en) * 1985-04-12 1991-04-30 Bristol-Myers Company Intermediates for the production of epipodophyllotoxin and related compounds and processes for the preparation and use thereof
JPS6310746A (ja) * 1986-07-01 1988-01-18 Tanabe Seiyaku Co Ltd ナフタレン誘導体
AT388372B (de) * 1987-10-08 1989-06-12 Tanabe Seiyaku Co Neue naphthalinderivate und sie enthaltende pharmazeutika
JPH01135766A (ja) * 1987-11-20 1989-05-29 Tanabe Seiyaku Co Ltd ビフェニル誘導体
PH26342A (en) * 1988-11-29 1992-04-29 Univ Texas Microbial cellulose modified during synthesis
MY105057A (en) * 1989-01-27 1994-07-30 Tanabe Seiyaku Co A process for preparing naphthalene derivatives
US5003087A (en) * 1989-02-03 1991-03-26 Tanabe Seiyaku Co., Ltd. Process for preparing a naphthalene derivative and a synthetic intermediate thereof
US5281720A (en) * 1991-02-28 1994-01-25 Merck Frosst Canada, Inc. Pyranylphenyl hydroxyalkylnaphthoic acids as inhibitors of leukotriene biosynthesis
EP0501578A1 (en) * 1991-02-28 1992-09-02 Merck Frosst Canada Inc. Pyranylphenyl hydroxyalkylnaphthoic acids as inhibitors of leukotriene biosynthesis
EP0501579A1 (en) * 1991-02-28 1992-09-02 Merck Frosst Canada Inc. Naphthalene lactones as inhibitors of leukotriene biosynthesis
US5227399A (en) * 1991-02-28 1993-07-13 Merck Frosst Canada, Inc. Pyranylphenyl naphthalene lactones as inhibitors of leukotriene biosynthesis
ES2091488T3 (es) * 1991-10-17 1996-11-01 Shionogi & Co Analogo de lignano, su produccion y medicamento hipolipidemico.
US5308852A (en) * 1992-06-29 1994-05-03 Merck Frosst Canada, Inc. Heteroarylnaphthalenes as inhibitors of leukotriene biosynthesis
US5252599A (en) * 1992-08-27 1993-10-12 Merck Frosst Canada, Inc. Heteroarylnaphthalene hydroxy acids as inhibitors of leukotriene biosynthesis
US5428060A (en) * 1992-08-27 1995-06-27 Merck Frosst Canada, Inc. Heteroarylnaphthalene lactones as inhibitors of leukotriene biosynthesis
US5350744A (en) * 1992-08-27 1994-09-27 Merck Frosst Canada, Inc. Phenylnaphthalene lactones as inhibitors of leukotriene biosynthesis
US5426109A (en) * 1992-08-27 1995-06-20 Merck Frosst Canada, Inc. Phenylnaphthalene hydroxy acids
CA2121060C (en) * 1993-04-16 2004-04-06 Sachio Mori Preparation of lignan analogues
ID18046A (id) * 1996-08-20 1998-02-19 Takeda Chemical Industries Ltd Senyawa siklik campuran, pembuatan dan penngunaannya.
CA2341540A1 (en) 1998-08-25 2000-03-02 Yale University Inhibition and treatment of hepatitis b virus and flavivirus by helioxanthin and its analogs
MXPA01012493A (es) 1999-06-01 2003-09-10 Univ Texas Southwestern Med Ct Metodo para tratar la perdida capilar con el uso de derivados de eter difenilico.
AR018699A1 (es) 1999-06-01 2001-11-28 Procter & Gamble Metodo para el tratamiento de la perdida del cabello el cual comprende administrar una composicion que comprende un compuesto el cual no afecta al corazon
US6680344B1 (en) 1999-06-01 2004-01-20 The University Of Texas Southwestern Medical Center Method of treating hair loss using diphenylmethane derivatives
SE0102168D0 (sv) * 2001-06-19 2001-06-19 Karolinska Innovations Ab New use and new compounds
AU2002328569B9 (en) * 2001-08-28 2005-10-27 Sankyo Company, Limited Medicinal compositions containing angiotensin II receptor antagonist
GB0307918D0 (en) 2003-04-05 2003-05-14 Astrazeneca Ab Therapeutic use
WO2011150286A2 (en) 2010-05-26 2011-12-01 Satiogen Pharmaceuticals,Inc. Bile acid recycling inhibitors and satiogens for treatment of diabetes, obesity, and inflammatory gastrointestinal conditions
CN107375932B (zh) 2011-10-28 2021-12-21 夏尔人类遗传性治疗公司 用于治疗小儿胆汁淤积性肝病的胆汁酸再循环抑制剂
JP6217939B2 (ja) 2011-10-28 2017-10-25 ルメナ ファーマシューティカルズ エルエルシー 高胆汁血症および胆汁うっ滞性肝疾患の処置のための胆汁酸再利用阻害剤
US20140275090A1 (en) 2013-03-15 2014-09-18 Lumena Pharmaceuticals, Inc. Bile acid recycling inhibitors for treatment of primary sclerosing cholangitis and inflammatory bowel disease
US20140271734A1 (en) 2013-03-15 2014-09-18 Lumena Pharmaceuticals, Inc. Bile acid recycling inhibitors for treatment of barrett's esophagus and gastroesophageal reflux disease
US20170119806A1 (en) * 2014-03-31 2017-05-04 Ohio State Innovation Foundation Arylnaphthalene lactone derivatives and methods of making and using thereof
US10682367B2 (en) 2016-02-26 2020-06-16 Ohio State Innovation Foundation Antitumor arylnaphthalene ligand glycosides
BR112021015809A2 (pt) 2019-02-12 2022-01-18 Mirum Pharmaceuticals Inc Resposta dependente de genótipo e dose a um asbti em pacientes com deficiência de bomba de exportação de sal biliar

Also Published As

Publication number Publication date
IL91117A0 (en) 1990-03-19
ES557052A0 (es) 1987-12-16
KR860005778A (ko) 1986-08-13
HUT42428A (en) 1987-07-28
JPH0549668B2 (en]) 1993-07-26
CN86100090A (zh) 1986-08-20
AU5175185A (en) 1986-07-17
FI860089A0 (fi) 1986-01-09
EP0188248B1 (en) 1990-07-11
NO170760B (no) 1992-08-24
BG45383A3 (bg) 1989-05-15
ATE54441T1 (de) 1990-07-15
HU196737B (en) 1989-01-30
FI860089L (fi) 1986-07-11
ES550578A0 (es) 1987-05-16
FI87557B (fi) 1992-10-15
JPH0272170A (ja) 1990-03-12
PH22105A (en) 1988-06-01
FI87557C (fi) 1993-01-25
AU584153B2 (en) 1989-05-18
JPH0272136A (ja) 1990-03-12
EP0188248A3 (en) 1986-12-17
PT81814A (en) 1986-02-01
DE3672501D1 (de) 1990-08-16
MY101268A (en) 1991-08-17
US5070103A (en) 1991-12-03
BG45385A3 (bg) 1989-05-15
PT81814B (pt) 1988-07-29
NO855355L (no) 1986-07-11
ES8801239A1 (es) 1987-12-16
KR890001884B1 (ko) 1989-05-29
DD270529A5 (de) 1989-08-02
JPS61267541A (ja) 1986-11-27
EP0188248A2 (en) 1986-07-23
CN1006464B (zh) 1990-01-17
ES8705837A1 (es) 1987-05-16
US4771072A (en) 1988-09-13

Similar Documents

Publication Publication Date Title
NO170760C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive nafthalenderivater
NO156690C (no) Analogifremgangsmaate ved fremstilling av terapeutisk aktive indanderivater.
HUT45230A (en) Process for producing new phenoxy-acetic acid derivatives and pharmaceuticals comprising such compounds
NO158017C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive imidazolderivater.
WO1994014833A3 (en) Substituted 6-azaandrostenones
NO834884L (no) Fremgangsmaate for fremstilling av farmakologisk aktive nitroalifatiske forbindelser
NO881835D0 (no) Fremgangsmaate for fremstilling av terapeutisk aktive bicykliske forbindelser.
CA2053477A1 (en) Heterocyclic amine derivatives, their production and use
EP0219852A3 (en) Chartreusin derivatives, salts thereof, antitumorous compositions containing the same, and processes for producing the same
NO163488C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive 1,5-benzothiazepin-derivater.
ES406081A1 (es) Procedimiento de preparacion de nuevos derivados del acido butirico.
ES8800140A1 (es) Un procedimiento para preparar un compuesto de n-fenil-trans-4-guanidincometilciclohexanocarboxamida.
ATE48994T1 (de) Benzimidazol-derivat, verfahren zu seiner herstellung und pharmazeutische zusammensetzung.
ES8104269A1 (es) Procedimiento para la preparacion de nuevos derivados de 3-amino-1-benzoxepina
EP0316939A3 (en) Biphenyl derivatives, preparation method, pharmaceutical compositions comprising them and use
DE3665309D1 (en) Novel peptides, compositions containing them and processes for their production
GR860045B (en) Novel piperazine derivatives processes for production thereof and pharmaceutical compositions comprising said compounds as active ingredient
SE7513126L (sv) Nya kvevehaltiga, polycykliska foreningar jemte sett for deras framstellning
US3028306A (en) Hypertensive 2-amino-3alpha, 4, 5, 6, 7, 7alpha-hexahydrobenzoxazole method and topical dosage preparation
GB1242096A (en) Benzobenzofuranooxepine compounds and process for preparing the same
GB1514572A (en) 2,5-methanobenzo(g)quinolines
GB1505859A (en) Azetidinone derivatives
DK644487A (da) Farmaceutisk praeparat indeholdende en 2-oxo-imidazolidinforbindelse
EP0035853A3 (en) Thienocycloheptapyrrole derivatives, process for their preparation and pharmaceutical compositions containing them
GB1110858A (en) Improvements in and relating to new sulphonamides,the process of preparation and theapplications thereof